CB1 Receptors

The Endocannabinoid System and Stress-Related Psychiatric Illness

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The Endocannabinoid System in Stress-Related Psychiatric Illness What is the endocannabinoid system (ECS)? For centuries cannabis has been used for relief from stress and anxiety suggesting that the compounds found in the plant regulate the body’s stress response, and in fact that’s just what researchers are finding. The endocannabinoid system (ECS) is a system of […]

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Cannabinoids and Memory

Cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD (Han, 2012): The hippocampus is an area of the brain that contains a high concentration of cannabinoid receptors and is involved in the formation of memories. Long-term depression (LTD) is a form of synaptic plasticity (cell signaling between neurons) that involves persistent weak […]

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Tylenol’s Analgesic Effect is Mediated By Cannabinoid Receptors

Acetaminophen, also known as Tylenol, is one of the most commonly used non-steroidal anti-inflammatory drugs (NSAIDs) for pain relief. But did you know that its compound’s pain fighting activity arises partially through its activity on the endocannabinoid system? The acidic cannabinoids (THCA and CBDA) along with non-acidic CBD exhibit anti-inflammatory properties by inhibiting enzymes called […]

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