Cannabis For Weight Loss?

Written by  Sunday, 02 February 2014 15:58

Recently researchers have discovered that the prevalence of obesity is paradoxically much lower in cannabis users as compared to non-users and that this difference is not accounted for by tobacco smoking status and is still present after adjusting for variables such as sex and age (Le Foll, 2013).  In abdominal obesity, the ECS is generally up-regulated in central and peripheral tissues and its blockade results in positive metabolic changes (Silvestri, 2012).  

A CB1 antagonist that attempted to harness these positive effects on weight loss was approved by the FDA in February 2006 under the name Rimonabant.  However, because CB1 antagonism in the central nervous system causes severe depression and suicidal thoughts the drug was removed from the market shortly after (O'Keefe, 2013).  

More recently researchers have focused on developing new CB1 antagonists that can't cross the blood brain barrier restricting them to the periphery. By using compounds that solely target the peripheral ECS, weight loss treatment using this strategy should no longer be accompanied by such negative psychological effects. 

The blog section of is intended to be used for educational and informational purposes only. and its editors and any affiliated entities and such entities' directors, officers, members, shareholders or employees, collectively "SCLabs" do not make any representations or warranties or advocate nutritional or herbal supplementation over proper medical advice or treatment. If using any pharmaceuticals or drugs given to you by a doctor you must consult with the doctor in question or an equally qualified Health Care Professional prior to using nutritional or herbal supplementation. SCLabs will not be liable for any errors or omissions in this information nor for the availability of this information. SCLabs will not be liable for any losses, injuries, or damages from the display or use of this information. You hereby agree to indemnify and hold SC Labs harmless for any adverse reactions to any nutritional or herbal supplementation.

Read 1913 times Last modified on Sunday, 08 June 2014 08:22