SC Labs President and Co-Founder Joshua Wurzer to speak at Harvard Medical School
It’s conference season and this year Massachusetts-based Medicinal Genomics is bringing together the best and brightest in cannabis for CannMed 2016, a two-day event at Harvard Medical School. Keynote speakers include Raphael Mechoulam, the researcher who discovered THC and Orrin Devinsky, the lead investigator in GW Pharmaceuticals trials using Epidolex for Dravet Syndrome.
The conference comes at a unique time as the advent of sequencing technology has enabled personalized medicine allowing for a better understanding of the genetic regulation of the endocannabinoid system. Conference topics include the use of cannabinoid therapeutics in neurological disorders and the role of the endocannabinoid system in such disorders.
SC Laboratories President Joshua Wurzer will also be presenting a lecture entitled “Chemotypic and Quality Control Analysis of the California Medical Cannabis Market.” Medicinal Genomics also plans to present their hypothesis on the current state of the testing market and its potential impact on the diversity of the cannabis microbiome.
Where: The Joseph B. Martin Conference Center at the Harvard School of Medicine, Boston, MA
When: April 10-11, 2016
More info at: http://www.medicinalgenomics.com/cannmed2016/
Skunky, fruity, floral, the bouquet of smells associated with cannabis can be highly diverse and varied from cultivar to cultivar. This diversity comes from the fragrant molecules found in cannabis called terpenes. There are over a hundred different terpenes found in cannabis, which have evolved with the cannabis plant as a defense mechanism against bacteria, fungi, insects, and other pests. They also serve as the building blocks for more complex molecules like the cannabinoids.
The Chemistry of Terpenes
Terpenes are volatile hydrocarbons that carry an aroma and are made up of small five carbon components called isoprene units. There are also similar molecules found in cannabis called terpenoids, which are modified terpenes where oxygen atoms have been incorporated or methyl groups have been added or removed. Often times the term terpenes is used more broadly to include terpenoids. Terpenes can be further categorized into three different subtypes: monoterpenes, diterpenes, and sesquiterpenes.
Photo taken from: http://www.ochempal.org/wp-content/images/I/isopreneunit.png
Monoterpenes are the simplest type of terpene and are made up of two isoprene…
SC Laboratories has been making quite the rounds lately in the news.
At the end of last month one of our co-founders Alec Dixon came to the aid of legalization efforts in Costa Rica alongside Valerie Corral of the Wo/Men's Alliance for Medical Marijuana (http://www.ticotimes.net/2015/02/24/marijuana-activists-push-legalization-of-medical-cannabis-in-costa-rica). About a week later we were also featured in the Mercury News regarding the growing demand for the quality of assurance testing of cannabis for medical use (http://www.mercurynews.com/bay-area-news/ci_27616995/marijuana-quality-testing-going-mainstream) Lastly, just yesterday we were featured on hightimes.com for our work on edible testing (http://www.hightimes.com/read/lab-tested-edibles-sc-labs-changing-game).
Expect to see a lot more of us as the rest of the country begins to recognize the importance of safe lab tested cannabis.
We’ve all heard of the “forgetful stoner”, and while some of us have better recall after excessive indulgence, others may have more difficulties. This is due to the modulation of certain signaling events within the neurons of cannabis users and over time differences in the structures of the brain responsible for memory formation. This article will explain what occurs at the structural and cellular level that corresponds with the hypomnesia associated with cannabis use.
Some Biological Concepts
Cannabinoid receptors are what are known as G-Protein Coupled Receptors (GPCRs). GPCRs are receptors that lead to signaling cascades, ultimately affecting the types of genes that are expressed in the cell. Once a ligand (a compound that has affinity for a receptor) binds to the receptor it can produce one of three responses. It can raise a receptor response above basal activity (agonist), cause a lack of response (antagonist), or cause activity to dip below basal levels (inverse agonist).
The binding of the ligand to the receptor leads to a signaling cascade that either decreases or increases the activity of a particular enzyme. These enzymes typically are responsible for the production of molecules known as secondary messengers. The amount of secondary messengers…
What is COPD?
Chronic obstructive pulmonary disease (COPD) is an illness characterized by increased production of mucus and chronic inflammation of the airways resulting in reduced respiratory capacity. The two primary forms of COPD are chronic bronchitis, which produces a long-term cough with mucus, and emphysema, which leads to the progressive deterioration of the alveoli, the air sacs that allow for gaseous exchange in the lungs.
How is COPD treated?
COPD is typically treated with two different types of compounds: beta-adrenergic agonists and corticosteroids. Beta-adrenergic agonists are bronchodilators, which relax the smooth muscle surrounding the respiratory tract resulting in an increased diameter of the bronchial passages facilitating airflow. There are two types of beta-agonists: short-acting beta-adrenergic agonists (SABAs) such as albuterol and long-acting beta-adrenergic agonists (LABAs) such as salmeterol. SABAs are typically utilized in the event of an acute attack of shortness of breath while LABAs are used as a prophylactic measure. LABAs are commonly co-administered with corticosteroids such as fluticasone, which acts as a preventative against immune-mediated inflammation of the airways. One such formulation of LABAs and corticosteroids is the drug Advair, a combination of salmeterol and fluticasone.
How might cannabis help…